Name: IGF-1 lR3 1mg (10 Vials / Kit)
Brand: Uther Peptide
SKU: UP-IGF-1-LR3-1MG
Price: 230.00 USD
Availability: InStock

What is IGF-1 LR3?

IGF-1 LR3 modifies native human IGF-1 by substituting arginine for glutamic acid at position 3 and adding a 13-residue extension at the N-terminus. These changes were designed specifically to reduce its affinity for the binding proteins that normally regulate native IGF-1 activity.

How it is understood to work

By evading binding proteins, IGF-1 LR3 remains active in solution far longer than native IGF-1, activating the IGF-1 receptor to drive PI3K/Akt and MAPK signaling cascades associated with cell proliferation, differentiation and protein synthesis.

Research status

It is a standard tool in cell-culture research, particularly studies of muscle satellite-cell proliferation, hypertrophy signaling and general growth-factor biology, where its extended activity window makes it useful compared with native IGF-1. It has not been developed as an approved therapeutic and clinical safety data in humans is limited.

This listing: Uther Peptide IGF-1 LR3

Brand: Uther Peptide
Kit: 10 vials × 1 mg (10 mg in total)
Price per vial: $23.00
Price per mg: $23.00
Also sold by: HK Peptide 1mg $200.00 · HK Peptide 0.1mg $34.00

Lab testing

Uther Peptide published a Janoshik report for this compound. Test: Identity & purity. Result: IGF 1 LR3 1MG. Tested Aug 29, 2025.

View the report · How to read it (Testing 101) · Every report for this compound

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: IGF-1 LR3
Also known as: Long R3 IGF-1
Class: Long-acting insulin-like growth factor 1 analog
Form: Lyophilized (freeze-dried) powder
Per vial: 1mg
Stated purity: ≥99%

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20 C protected from light, and after reconstitution with bacteriostatic water keep refrigerated and use within the timeframe set by the study protocol.

Concentration check: adding 2 ml of bacteriostatic water to one 1 mg vial gives 0.5 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

Why use IGF-1 LR3 instead of native IGF-1 in a study?

Native IGF-1 is rapidly bound and cleared from solution, giving it a half-life of minutes; the LR3 modification resists that binding, giving researchers a longer, more stable signaling window for in vitro work.

Does IGF-1 LR3 activate the insulin receptor as well?

At sufficiently high concentrations IGF-1 LR3 can cross-react with the insulin receptor, which is a consideration researchers account for when interpreting metabolic versus growth-signaling data in a given assay.

How much IGF-1 LR3 is in this kit?

10 vials of 1 mg each, so 10 mg in total. The lab testing section above shows what the brand’s tested vial actually contained.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.