Name: MOTS-c 10mg (10 Vials / Kit)
Brand: HK Peptide
SKU: HK-MS10
Price: 50.00 USD
Availability: InStock

What is MOTS-c?

MOTS-c belongs to a small class of mitochondrial-derived peptides, meaning its coding sequence lies within the mitochondrial genome rather than nuclear DNA, specifically within the 12S rRNA region. This origin sets it apart from most research peptides, which are modeled on nuclear-encoded proteins or hormones, and has made it a focus of mitochondrial-signaling research.

How it is understood to work

MOTS-c is studied for activating the AMPK energy-sensing pathway and influencing the folate-methionine metabolic cycle, effects linked in cell and animal models to improved glucose uptake and insulin sensitivity. Under metabolic stress, it has also been reported to translocate to the cell nucleus, where it may participate in regulating adaptive gene-expression programs.

Research status

Published work spans cell culture and rodent models of insulin resistance, diet-induced obesity, exercise capacity and age-related metabolic decline, framing MOTS-c as a candidate signaling molecule linking mitochondrial state to whole-body metabolism; it has not progressed to human clinical trials or approved use, and its physiological role outside laboratory models is still being defined.

This listing: HK Peptide MOTS-c

Brand: HK Peptide
Kit: 10 vials × 10 mg (100 mg in total)
Price per vial: $5.00
Price per mg: $0.50
Other strengths: 40mg $180.00
Also sold by: Uther Peptide 10mg $65.00 · Uther Peptide 20mg $110.00 · Uther Peptide 40mg $210.00

Lab testing

HK Peptide published a Janoshik #148114 report for this compound. Test: Purity & Content (HPLC). Result: 99.06% purity · 11.12 mg. Tested Apr 10, 2026. Verification key JXI21LZJTPEB can be checked at janoshik.com.

View the report · How to read it (Testing 101) · Every report for this compound

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA-c
Class: Mitochondrial-derived peptide (16 amino acids)
Form: Lyophilized (freeze-dried) powder
Per vial: 10mg
Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6 g/mol
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Stated purity: ≥99% (HPLC)
Appearance: White lyophilized powder

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20C protected from light, and once reconstituted with bacteriostatic water keep refrigerated at 2-8C for use within the study’s defined timeframe.

Concentration check: adding 2 ml of bacteriostatic water to one 10 mg vial gives 5 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

How is MOTS-c different from other metabolic peptides like retatrutide?

MOTS-c is a naturally occurring, mitochondrially encoded signaling peptide studied mainly for intracellular energy-sensing pathways such as AMPK, whereas retatrutide is a fully synthetic, engineered receptor agonist targeting GLP-1, GIP and glucagon receptors from outside the cell.

What should a COA verify for MOTS-c?

Sequence confirmation of the 16-residue chain, molecular weight near 2174.6 g/mol, and HPLC purity of 99% or higher, since the peptide’s methionine and cysteine-adjacent residues can be prone to oxidation if handled or tested improperly.

How much MOTS-c is in this kit?

10 vials of 10 mg each, so 100 mg in total. The lab testing section above shows what the brand’s tested vial actually contained.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.