KPV

What is KPV?

KPV (Lys-Pro-Val) corresponds to residues 11-13 of alpha-melanocyte-stimulating hormone, the smallest fragment reported to retain meaningful biological activity from the parent peptide. Because it lacks the sequence responsible for melanocortin receptor-driven pigmentation, researchers use it to isolate alpha-MSH’s anti-inflammatory effects from its pigment-related actions.

This listing is KPV from Vital Edge Science (Australia & New Zealand), sold on Stairway to Gray with escrow: your payment is held until the order arrives and only then released to the brand.

How it is understood to work

KPV is studied for its ability to enter cells via the PepT1 peptide transporter, which is highly expressed in intestinal and skin tissue, and to inhibit NF-kB signaling once inside, reducing production of pro-inflammatory cytokines. Some in vitro work also describes direct antimicrobial activity against certain bacterial strains.

Research status

The tripeptide has been examined mainly in cell culture and rodent models of colitis, inflammatory bowel conditions, dermatitis and wound healing; it has not been evaluated in registered human clinical trials, and its transporter-dependent uptake means results can vary meaningfully between tissue types used in different study models.

Specifications

Compound

KPV

Also known as

Lys-Pro-Val, alpha-MSH(11-13)

Class

Naturally occurring tripeptide, C-terminal alpha-MSH fragment

Form

Lyophilized (freeze-dried) powder

Sequence

Lys-Pro-Val

Brand

Vital Edge Science · Australia & New Zealand

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20C protected from light, and once reconstituted with bacteriostatic water keep refrigerated at 2-8C for use within the study’s defined timeframe.

Questions

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.