Name: FOX04 10mg (10 Vials / Kit)
Brand: Uther Peptide
SKU: UP-FOXO4-10MG
Price: 350.00 USD
Availability: InStock

What is FOXO4-DRI?

FOXO4-DRI is a synthetic peptide built using D-amino acids in reverse sequence order, a design known as retro-inverso that is intended to resist normal proteolytic breakdown while still binding its target. It was designed specifically to interfere with a protein-protein interaction implicated in why senescent cells resist programmed cell death.

How it is understood to work

In senescent cells, the transcription factor FOXO4 binds and retains p53 in the nucleus, which blocks the apoptosis pathway p53 would otherwise trigger. FOXO4-DRI competitively binds FOXO4, and in preclinical models this releases p53 to the cytoplasm and selectively induces apoptosis in senescent cells while leaving healthy cells comparatively unaffected.

Research status

The senolytic concept behind FOXO4-DRI was described in a widely cited 2017 study that reported improved fitness, coat condition, and kidney function in aged and progeroid mice. Subsequent research has used it in models of chemotherapy-induced senescence and tissue regeneration in aged animals, but this work remains at the animal and cell-culture stage, with no human clinical development reported.

This listing: Uther Peptide FOXO4-DRI

Brand: Uther Peptide
Kit: 10 vials × 10 mg (100 mg in total)
Price per vial: $35.00
Price per mg: $3.50
Also sold by: HK Peptide 10mg $290.00

Lab testing

Uther Peptide published a Janoshik report for this compound. Test: Identity & purity. Result: Fox04 10mg. Tested Aug 21, 2025.

View the report · How to read it (Testing 101) · Every report for this compound

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: FOXO4-DRI
Also known as: FOXO4-D-Retro-Inverso peptide
Class: D-retro-inverso peptide (senolytic research tool)
Form: Lyophilized (freeze-dried) powder
Per vial: 10mg
Stated purity: ≥99% (HPLC)

Handling & storage

Supplied as a lyophilized powder; keep unopened vials frozen and protected from light, and once reconstituted with bacteriostatic water, store refrigerated and use within your protocol’s defined timeframe.

Concentration check: adding 2 ml of bacteriostatic water to one 10 mg vial gives 5 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

What does ‘D-retro-inverso’ mean for this peptide?

It means the amino-acid sequence is reversed and built from D-amino acids instead of the natural L-form, a design intended to preserve the side-chain topology needed for target binding while making the peptide far more resistant to normal enzymatic degradation.

Is FOXO4-DRI the same as other senolytic compounds like dasatinib and quercetin?

No, it works through a distinct, peptide-based mechanism targeting the FOXO4-p53 interaction rather than the different molecular targets of small-molecule senolytics, so the two approaches are studied as separate, mechanistically distinct research strategies.

How much FOXO4-DRI is in this kit?

10 vials of 10 mg each, so 100 mg in total. The lab testing section above shows what the brand’s tested vial actually contained.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.