Name: MOTS-c
Brand: Lilipeptide
SKU: LILI-mots-c
Price: 84.00 USD
Availability: InStock

What is MOTS-c?

MOTS-c belongs to a small class of mitochondrial-derived peptides, meaning its coding sequence lies within the mitochondrial genome rather than nuclear DNA, specifically within the 12S rRNA region. This origin sets it apart from most research peptides, which are modeled on nuclear-encoded proteins or hormones, and has made it a focus of mitochondrial-signaling research.

This listing is MOTS-c from Lilipeptide (China), sold on Stairway to Gray with escrow: your payment is held until the order arrives and only then released to the brand.

How it is understood to work

MOTS-c is studied for activating the AMPK energy-sensing pathway and influencing the folate-methionine metabolic cycle, effects linked in cell and animal models to improved glucose uptake and insulin sensitivity. Under metabolic stress, it has also been reported to translocate to the cell nucleus, where it may participate in regulating adaptive gene-expression programs.

Research status

Published work spans cell culture and rodent models of insulin resistance, diet-induced obesity, exercise capacity and age-related metabolic decline, framing MOTS-c as a candidate signaling molecule linking mitochondrial state to whole-body metabolism; it has not progressed to human clinical trials or approved use, and its physiological role outside laboratory models is still being defined.

This listing: Lilipeptide MOTS-c

Brand: Lilipeptide
Also sold by: Vital Edge Science MOTS-C $112.00 · Peptide Express 10mg $40.00 · EuropePeptide 10mg $39.99 · Cyprus Peptides 10mg $152.00 · Lab77 Peptides 10mg $44.00 · Imperial Peptides 10mg $33.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: MOTS-c
Also known as: Mitochondrial ORF of the 12S rRNA-c
Class: Mitochondrial-derived peptide (16 amino acids)
Form: Lyophilized (freeze-dried) powder
Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular weight: 2174.6 g/mol
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro
Brand: Lilipeptide · China

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20C protected from light, and once reconstituted with bacteriostatic water keep refrigerated at 2-8C for use within the study’s defined timeframe.

Questions

How is MOTS-c different from other metabolic peptides like retatrutide?

MOTS-c is a naturally occurring, mitochondrially encoded signaling peptide studied mainly for intracellular energy-sensing pathways such as AMPK, whereas retatrutide is a fully synthetic, engineered receptor agonist targeting GLP-1, GIP and glucagon receptors from outside the cell.

What should a COA verify for MOTS-c?

Sequence confirmation of the 16-residue chain, molecular weight near 2174.6 g/mol, and HPLC purity of 99% or higher, since the peptide’s methionine and cysteine-adjacent residues can be prone to oxidation if handled or tested improperly.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.