Name: Semax 5mg (10 Vials / Kit)
Brand: HK Peptide
SKU: HK-XA5
Price: 40.00 USD
Availability: InStock

What is Semax?

Semax is built from the ACTH(4-7) fragment of adrenocorticotropic hormone, extended with a Pro-Gly-Pro sequence that improves metabolic stability. Despite its ACTH lineage, it does not retain the hormone’s corticotropic (adrenal-stimulating) activity.

How it is understood to work

Semax is studied for its ability to increase expression of brain-derived neurotrophic factor (BDNF) and its TrkB receptor, along with modulation of dopaminergic and serotonergic signaling and antioxidant activity in models of reduced blood flow to brain tissue.

Research status

It is approved and marketed as a nasal-spray medicine in Russia for conditions including stroke recovery and certain cognitive complaints, though it has not received FDA or EMA approval and is not an approved medicine in the US or EU. Outside that regulatory context, it is studied preclinically for cognition, memory, attention and neuroprotection.

This listing: HK Peptide Semax

Brand: HK Peptide
Kit: 10 vials × 5 mg (50 mg in total)
Price per vial: $4.00
Price per mg: $0.80
Other strengths: 11mg $70.00
Also sold by: Uther Peptide 10mg $60.00

Lab testing

HK Peptide published a Janoshik #107748 report for this compound. Test: Purity & Content (HPLC). Result: 99.33% purity · 11.30 mg. Tested Feb 13, 2026. The vial tested was a different strength than this listing, so treat it as evidence for the compound and ask for the batch COA for this exact strength. Verification key 962A5E58THAT can be checked at janoshik.com.

View the report · How to read it (Testing 101) · Every report for this compound

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: Semax
Also known as: ACTH(4-10) analog
Class: Synthetic ACTH-fragment neuropeptide
Form: Lyophilized (freeze-dried) powder
Per vial: 5mg
Molecular formula: C₃₇H₅₁N₉O₁₀S
Molecular weight: 813.9 g/mol
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Stated purity: ≥99% (HPLC)
Appearance: White lyophilized powder

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20 C protected from light, and after reconstitution with bacteriostatic water keep refrigerated and use within the timeframe set by the study protocol.

Concentration check: adding 2 ml of bacteriostatic water to one 5 mg vial gives 2.5 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

Is Semax the same as ACTH, and does it affect cortisol?

No. Although derived from an ACTH fragment, Semax’s structural modifications remove the corticotropic activity responsible for stimulating adrenal cortisol production, which is why it is studied for CNS effects rather than endocrine ones.

Is Semax an approved medicine anywhere?

Yes, it is approved and sold as a prescription nasal spray in Russia, but it has not been approved by the FDA or EMA, so its regulatory status differs substantially between regions.

How much Semax is in this kit?

10 vials of 5 mg each, so 50 mg in total. The lab testing section above shows what the brand’s tested vial actually contained.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.