Name: PE 22-28 10mg (10 Vials / Kit)
Brand: TFC Peptides
SKU: TFC-PE10
Price: 45.00 USD
Availability: InStock

What is PE-22-28?

PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) corresponds to residues 22-28 of the sortilin propeptide, the precursor from which the endogenous peptide spadin is cleaved. It was identified in a 2017 study that searched for the shortest spadin fragment that kept its biological activity.

This listing is PE-22-28 (10 vials × 10mg) from TFC Peptides (Tianjin, China), sold on Stairway to Gray with escrow: your payment is held until the order arrives and only then released to the brand.

How it is understood to work

Spadin and its analogs block TREK-1, a two-pore-domain potassium channel implicated in mood regulation; mice lacking TREK-1 show a depression-resistant phenotype. In HEK cells expressing human TREK-1, PE-22-28 inhibited the channel at sub-nanomolar concentrations, markedly more potently than full-length spadin.

Research status

Published work is preclinical: rodent behavioral models of depression, measures of hippocampal neurogenesis and synaptic markers, and electrophysiology on cloned channels. The analogs were reported to act faster and last longer than spadin in these models, but no human clinical trials have been published.

This listing: TFC Peptides PE-22-28

Brand: TFC Peptides
Kit: 10 vials × 10 mg (100 mg in total)
Price per vial: $4.50
Price per mg: $0.45
Also sold by: Jinlu Peptides 10mg $150.00 · SSRBIO 10mg $54.00 · Uther Peptide 10mg $80.00

Lab testing

There is no public lab report for this listing yet. We can ask the brand for the batch COA before you order. Many buyers also split an independent HPLC test with others who bought the same batch.

Request the batch COA · How group testing works

Bought through escrow: the brand is only paid after you confirm delivery. If the parcel never arrives, or an independent test shows the wrong compound or a significant under-fill, open a claim before releasing payment.

Specifications

Compound: PE-22-28
Also known as: Spadin analog, GVSWGLR
Class: Shortened spadin analog, TREK-1 channel inhibitor
Form: Lyophilized (freeze-dried) powder
Per vial: 10mg
Units per kit: 10
Brand: TFC Peptides · Tianjin, China

Handling & storage

Supplied as a lyophilized powder; store unopened vials at -20C away from light, and keep any reconstituted solution refrigerated at 2-8C for short-term use.

Concentration check: adding 2 ml of bacteriostatic water to one 10mg vial gives 5 mg/ml. The Research Lab calculator in your dashboard works this out for any volume.

Questions

How is PE-22-28 related to spadin?

Spadin is a 17-amino-acid peptide released from the sortilin propeptide. PE-22-28 keeps only seven of those residues, which researchers found retained, and in cell assays improved, TREK-1 inhibition.

What should its COA confirm?

An HPLC purity figure and a mass-spec result matching the expected molecular weight for GVSWGLR (about 802 Da), plus the measured content per vial against the labeled amount.

How much PE-22-28 is in this kit?

10 vials of 10mg each. The lab testing section above shows what the brand’s tested sample actually contained, where a report exists.

For laboratory research use only. Not for human or veterinary use. Nothing on this page is medical advice.