Dictionary of Terms

ADA

Antidrug Antibodies that can develop in patients and can potentially affect drug pharmacokinetics, safety, and efficacy of the injected peptide. ADA response did not affect tirzepatide pharmacokinetics or efficacy during SURPASS Phase 3 FDA trials.

API

Active pharmaceutical ingredient. The main active ingredient in the vial. i.e. tirzepatide

Bacteriostatic water (BAC)

Water that has 0.9% benzyl alcohol in it to keep bacteria from growing further. pH balance is very important for ISR and should always use Pfizer Hospira bacteriostatic water.

COA

Certificate of Analysis that typically tests for purity and quantity. Done using High Performance Liquid Chromatography (HPLC) usually by PeptideTest and Janoshik.

Counterion

A counterion salt form of a pharmaceutical drug is created by combining the active ingredient (API) with a charged counterpart (the counterion) to form a stable compound. This form improves properties like solubility, stability, or shelf life, making the drug easier to manufacture, store, and administer.

Deamidation

Deamidation is a chemical change where a part of the peptide (like asparagine or glutamine) lose a small piece (an amide group), turning into different molecules. This can make the peptide less stable and less effective. Deamidation is accounted for in the purity results you see in HPLC tests.

Endocrine System

The endocrine system is a group of glands in the body that produce hormones, which control many bodily functions. Hunger response is just one of the many functions that our endocrine system regulates.

GLP1

Glucagon-like peptide medicine class that tirzepatide is a part of. Used in T2D and obesity treatment drugs.

Gray Market

Buying “for research only” lyophilized tirzepatide instead of liquid tirzepatide from a compound pharmacy.

Group Buy

1. Vendor-managed sale or promotion: Guarantees purity and overfill or offers reshipment. Ships from the vendor’s warehouse and is generally safer from scams.
2. Third-party individual-managed sale: Buys 1,000+ vials and is almost always a scam. DO NOT DO THIS. These are high-risk with low accountability and many have been scammed.

Injection Site Reaction (ISR)

Sometimes a stinging sensation upon injection or redness that develops shortly after. ISR can result from your body releasing histamines, pH imbalances in the recon solution, or other factors.

LTEV

Linked To Each Vial. When a test is done and associated with a batch number for each vial, typically provided by a tirzepatide supplier.

MOQ

Minimum Order Quantity. Many providers require a minimum spending amount or quantity of kits to place an order. Some also set minimums for free shipping.

Peptides

A broad class of molecules, including tirzepatide.

Powder

1. Lyophilized Powder: Freeze-dried powder form of tirzepatide, typically in vacuum-sealed vials. Powder may appear loose or as a solid puck; both forms are of equal quality.
2. Raw Powder: The raw form of tirzepatide, without mannitol or other fillers needed for lyophilization. Avoid purchasing bulk raw powder sold in gram to kilogram amounts, as it is less shelf-stable and difficult to dose at mg levels without specialized equipment.

Reconstitution

The process of adding bacteriostatic water to peptides to create a liquid solution. This is how injectable tirzepatide is made from lyophilized powder.

RS

Research Subject. Refers to individuals administered tirzepatide for research purposes.

SPPS

Solid-Phase Peptide Synthesis is the type of manufacturing technique used to create tirzpeatide. First mentioned in Eli Lily’s 2016 patents for tirzepatide.

Sterility Test

A supplementary test to the COA. It involves reconstituting powder with regular water (not BAC) and applying it to culture media (e.g., broth or agar) to observe bacterial growth over weeks.

• TAMC: Total Aerobic Microbial Count (sterility test by Janoshik).
• TYMC: Total Yeast and Mold Count (sterility test by Janoshik).
• USP71: US Pharmacopeia 71 sterility test by Peptidetest.

Third Party Testing (3P)

When an end-user independently tests their tirzepatide and shares individual results. Considered superior to provider testing but inferior to self-testing.

USP

US Pharmacopeia standard. Refers to pharmaceutical-grade standards followed in FDA-regulated spaces.

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